产品属性：

商品介绍：

英文名称phospho-STAT3 (Ser727) Recombinant Rabbit mAb

中文名称磷酸化信号转导和转录激活因子3重组兔单抗

别    名STAT3(phospho S727); p-STAT3(phospho S727); STAT3(phospho Ser727); STAT3(phospho S727); p-STAT3(Ser727); Acute Phase Response Factor; APRF; DNA binding protein APRF; Signal Transductor and Activator of Transcription 3; STAT 3; STAT3_HUMAN.  

产品类型磷酸化抗体 重组兔单抗

研究领域肿瘤  细胞生物  免疫学  信号转导  细胞凋亡  转录调节因子  

抗体来源Rabbit

克隆类型Recombinant

克 隆 号4G1

交叉反应Human,Mouse,Rat

产品应用WB=1:500-2000,IHC-P=1:200-800,IHC-F=1:200-800,IF=1:200-800,ICC/IF=1:100-500

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

理论分子量88 kDa

检测分子量

细胞定位细胞核 细胞浆

性    状Liquid

浓    度1mg/ml

免 疫 原A synthesized peptide derived from human STAT3 around the phosphorylation site of S727: PM-pS-PR

亚    型IgG

纯化方法affinity purified by Protein A

缓 冲 液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PubMedPubMed
phospho-STAT3 (Ser727) Recombinant Rabbit mAb产品介绍STATs (signal transducers and activators of transcription) were originally discovered as two proteins (STAT1 and STAT2) which were involved in interferon alpha (IFN alpha) and IFN gamma signal transduction. Since then, several additional STAT proteins have been identified (STAT3, 4, 5a, 5b, and 6). STATs undergo tyrosine phosphorylation in response to growth factor or cytokine signaling. This phosphorylation results in dimerization and translocation of STAT proteins to the nucleus. In some cases this process is mediated by JAK Kinases (Janus Kinases 1, 2, and 3). For maximum activation of these proteins, phosphorylation at specific tyrosine and serine residues may be required in STAT1 alpha, 3, 4, and 5. Specific functions of the various members of the STAT family are poorly understood. STAT3 has been shown to be activated by IFN alpha but not IFN beta. The transcription factors associated with STAT3 are cJun and cyclic AMP responsive enhancer binding protein (CREB). Deletion of the STAT3 gene in knock out mice was lethal at the early embryonic stage.