产品属性：

商品介绍：

英文名称PDGF Receptor beta Recombinant Rabbit mAb

中文名称血小板源性生长因子受体B/PDGFRβ重组兔单抗

别    名Platelet-derived growth factor receptor beta; CD140B; beta platelet derived growth factor receptor; beta-type platelet-derived growth factor receptor; CD 140B; CD140 antigen-like family member B; CD140B; CD140b antigen; JTK12; OTTHUMP00000160528; PDGF R beta; PDGF-R-beta; PDGFR; PDGFR1; PDGFRB; PGFRB_HUMAN; Platelet derived growth factor receptor beta polypeptide; PDGF Receptor beta; beta-type platelet-derived growth factor receptor precursor;  

抗体来源Rabbit

克隆类型Recombinant

克 隆 号3A3

交叉反应Human,Mouse,Rat

产品应用WB=1:1000-5000,IHC-P=1:200-800,IHC-F=1:200-800,IF=1:200-800

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

理论分子量118 kDa

检测分子量

细胞定位细胞浆 细胞膜

性    状Liquid

免 疫 原A synthesized peptide derived from human PDGFR beta: 1051-1106

亚    型IgG

纯化方法affinity purified by Protein A

缓 冲 液0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PubMedPubMed
PDGF Receptor beta Recombinant Rabbit mAb产品介绍The PDGF Receptor Type A (Alpha platelet-derived growth factor receptor precursor, CD140a antigen), a 170kD protein, binds all three isoforms of PDGF with high affinity whereas the PDGF Receptor Type B, a 190kD protein, appears to bind only the PDGF BB homodimer with high affinity. Both receptors are transmembranous, ligand activated protein tyrosine kinases, which phosphorylate a number of important signal transduction proteins, which are bound with differential affinities via SH2 domains. The response of any given cell to PDGF will depend on the types of receptors displayed on the surface and isoforms of PDGF present in the extracellular environment.