产品属性：

商品介绍：

英文名称Claudin 18.2 Recombinant Rabbit mAb

中文名称紧密连接蛋白18重组兔单抗

别    名CLD18_HUMAN; Claudin-18; Claudin18; CLDN18; UNQ778/PRO1572; SFTA5; SFTPJ; CLDN18.2; Claudin-18.2; Claudin18.2;  

研究领域细胞生物  信号转导  转运蛋白  细胞粘附分子  内皮细胞  跨膜蛋白  

抗体来源Rabbit

克隆类型Recombinant

克 隆 号R7G12

交叉反应Human,Mouse,Rat

产品应用IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

理论分子量28 kDa

检测分子量

细胞定位细胞膜

性    状Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human Claudin-18.2

亚    型IgG

纯化方法affinity purified by Protein A

缓 冲 液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PubMedPubMed
Claudin 18.2 Recombinant Rabbit mAb产品介绍The Claudin superfamily consists of many structurally related proteins in humans (1). These proteins are important structural and functional components of tight junctions in paracellular transport (1,2). Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues (1). Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and Junction adhesion molecule (3). Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands (4). Emerging evidence suggests that the Claudin family of proteins regulates transport through tight junctions via differential discrimination for solute size and charge (5).Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions (6).