英文名称AACT Recombinant Rabbit mAb

中文名称α-1抗胰糜蛋白酶/SERPINA3重组兔单克隆抗体

别    名AACT_HUMAN; SERPINA3; alpha-1-antichymotrypsin; ACT; Cell growth-inhibiting gene 24/25 protein; Serpin A3; GIG24; GIG25; serpin family A member 3;  

抗体来源Rabbit

克隆类型Recombinant

克 隆 号A12D5

交叉反应Human

产品应用WB=1:2000-10000,IHC-P=1:200-800,IHC-F=1:200-800,IF=1:200-800

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

理论分子量45 kDa

检测分子量

细胞定位分泌型蛋白

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原Full length native Protein: 1-423/423

亚    型IgG

纯化方法affinity purified by Protein A

缓 冲 液PBS, Glycerol, BSA.

保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PubMedPubMed
AACT Recombinant Rabbit mAb产品介绍Alpha 1-Antichymotrypsin, a member of the serine proteinase inhibitor (serpin) family, inhibits neutrophil proteinase cathepsin G and mast cell chymases, and protects the lower respiratory tract from damage by proteolytic enzymes. It contains a reactive centre loop, which interacts with cognate proteinases, resulting in loop cleavage and a major conformational change. Recently, alpha 1-antichymotrypsin has been identified as a major constituent of the neurofibrillary plaques associated with Alzheimers disease, and in vitro studies have shown that it enhances the rate of amyloid-fibril formation. These observations and recent genetic evidence suggest that alpha 1-antichymotrypsin is important in the pathogenesis of Alzheimers disease.