化学性质:
规格 | 5mg 10mg 50mg 100mg |
CAS | 2234281-75-3 |
别名 | N/A |
化学名 | N/A |
分子式 | C22H24N2O3 |
分子量 | 364.44 |
溶解度 | DMSO : 125 mg/mL (342.99 mM) |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
JI051 is a stabilizer for the Hes1-PHB2 interaction, interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity[1].
JI051 causes G2/M cell-cycle arrest[1].JI051 (0.1-10 μM, 24 hours) significantly inhibits cell proliferation of HEK293 cells, with an EC50 of 0.3 μM[1]. Cell Proliferation Assay[1] Cell Line: HEK293 cells
[1]. Perron A, et al. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. J Biol Chem. 2018 May 25;293(21):8285-8294.
特别提醒:
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2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
标签:JI051
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