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抑制剂 > 癌症生物学 > Phenformin-d5 (hydrochloride)
产品名称:
Phenformin-d5 (hydrochloride)
型号:
CS-01Y78589
生产地址
国产
产品价格
电议
产品简介
质量保证、价格优惠
产品详情

一、概述:

化学性质:                                                                                                             

规格

500 μg 1 mg 5 mg 10 mg

CAS

N/A

别名

N/A

化学名

N/A

分子式

C10H10D5N5 ? HCl

分子量

246.8

溶解度

DMF: 33 mg/mL,DMSO: 33 mg/mL,Ethanol: 10 mg/mL,PBS (pH 7.2): 5mg/mL

储存条件

-20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

 

产品描述:                                                                                                            

Phenformin-d5 is intended for use as an internal standard for the quantification of phenformin by GC- or LC-MS. Phenformin is an antihyperglycemic biguanide.1 It reduces blood glucose levels in a mouse model of diabetes induced by alloxan when administered at a dose of 100 mg/kg. Phenformin (250 mg/kg) induces lactic acidosis in diabetic dogs.2 It also inhibits tumor growth of MCF-7 and MDA-MB-231 breast cancer mouse xenograft models when administered at a dose of 300 mg/kg.3 Formulations containing phenformin were previously used in the treatment of diabetes mellitus.

1.Li, W.-L., Wu, J.-L., Ren, B.-R., et al.Pharmacological studies on anti-hyperglycemic effect of folium eriobotryaeAm. J. Chin. Med.35(4)705-711(2007) 2.Arieff, A.I., Park, R., Leach, W.J., et al.Pathophysiology of experimental lactic acidosis in dogsAm. J. Physiol.239(2)F135-F142(1980) 3.Appleyard, M.V.C.L., Murray, K.E., Coates, P.J., et al.Phenformin as prophylaxis and therapy in breast cancer xenograftsBr. J. Cancer106(6)1117-1122(2012)

特别提醒:                                                                                                              

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。

标签:Phenformin-d5 (hydrochloride) 

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