N-Nitroso-N-methyl-4-Aminobutyric AcidCS-01Y78577_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	10 mg 25 mg 50 mg 100 mg
CAS	61445-55-4
别名	N/A
化学名	N/A
分子式	C5H10N2O3
分子量	146.1
溶解度	DMF: 30mg/mL,DMF:PBS (pH 7.2) (1:7): 0.12mg/mL,DMSO: 20mg/mL,Ethanol: 25mg/mL
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) is a tobacco-specific nitrosamine carcinogen.1 It is oxidized to the reactive metabolite methyl-2-oxopropylnitrosamine (MOPN) in isolated rat liver mitochondria.2 NMBA induces bladder transitional cell carcinomas in rats when administered in the drinking water at a concentration of 300 mg/L per day.3

1.Djordjevic, M.V., Brunnemann, K.D., and Hoffmann, D.Identification and analysis of a nicotine-derived N-nitrosamino acid and other nitrosamino acids in tobaccoCarcinogenesis10(9)1725-1731(1989) 2.Janzowski, C., Landsiedel, R., G?lzer, P., et al.Mitochondrial formation of β-oxopropyl metabolites from bladder carcinogenic ω-carboxyalkylnitrosaminesChem. Biol. Interact.90(1)23-33(1994) 3.Lijinsky, W., Reuber, M.D., Saavedra, J.E., et al.Carcinogenesis in F344 rats by N-nitrosomethyl-n-propylamine derivativesJ. Natl. Cancer Inst.70(5)959-963(1983)

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标签：N-Nitroso-N-methyl-4-Aminobutyric Acid

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