PFM39CS-01Y78573_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	25 mg 50 mg 100 mg
CAS	1310744-67-2
别名	N/A
化学名	N/A
分子式	C10H9N3OS
分子量	219.26
溶解度	N/A
储存条件	4°C, protect from light
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

PFM39, a Mirin analog, is a potent and selective MRE11 exonuclease inhibitor. PFM39 inhibits phosphate rotation for dsDNA exonuclease activity. PFM39 does not inhibits TmMre11 or human MRE11/MRN endonuclease activity[1].

PFM39 (100 μM) treatment impairs G2-phase double-strand break (DSB) repair in 1BR3-hTERT fibrolasts following ionizing irradiation (IR)[1]. PFM39 (50 μM) inhibits homologous recombination (HR) without significantly increasing NHEJ[1].

[1]. Atsushi Shibata , et al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014 Jan 9;53(1):7-18.

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标签：PFM39

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