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Phenoxazine is a heterocyclic building block.1 It has been used in the synthesis of phenoxazine derivatives that have anticancer and antimicrobial activities in vitro.2,3 Phenoxazine has also been used in the synthesis of phenoxazine derivatives used as chromogenic substrates.4

1.Shruti, Dwivedi, J., Kishore, D., et al.Recent advancement in the synthesis of phenoxazine derivatives and their analoguesSynthetic Commun.48(12)1377-1402(2018) 2.Shimizu, S., Suzuki, M., Tomoda, A., et al.Phenoxazine compounds produced by the reactions with bovine hemoglobin show antimicrobial activity against non-tuberculosis mycobacteriaTohoku J. Exp. Med.203(1)47-52(2004) 3.Che, X.-F., Zheng, C.-L., Akiyama, S.-I., et al.2-Aminophenoxazine-3-one and 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine-3-one cause cellular apoptosis by reducing higher intracellular pH in cancer cellsProc. Jpn. Acad. Ser. B Phys. Biol. Sci.87(4)199-213(2011) 4.Jana, N.C., Patra, M., Brand?o, P., et al.Synthesis, structure and diverse coordination chemistry of cobalt(III) complexes derived from a Schiff base ligand and their biomimetic catalytic oxidation of o-aminophenolsPolyhedron16423-34(2019)

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