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Penicinoline is an alkaloid that has been found in Penicillium and has antimalarial, insecticidal, and anticancer activities.1,2 It is active against chloroquine-sensitive and -resistant strains of P. falciparum (IC50 = 25 μM for both).1 Penicinoline (1,000 ppm) is also active against the aphid A. gossypii.2 It inhibits proliferation of 95-D and HepG2 cancer cells (IC50s = 0.57 and 6.5 μg/ml, respectively) but not HeLa, KB, KBv200, or Hep-2 cells (IC50s = >100 μg/ml).

|1. Naveen, B., Ommi, N.B., Mudiraj, A., et al. Total synthesis of penicinoline E, marinamide, methyl marinamide and their antimalarial activity. ChemistrySelect 2(11), 3256-3261 (2017).|2. Shao, C.-L., Wang, C.-Y., Gu, Y.-C., et al. Penicinoline, a new pyrrolyl 4-quinolinone alkaloid with an unprecedented ring system from an endophytic fungus Penicillium sp. Bioorg. Med. Chem. Lett. 20(11), 3284-3286 (2010).

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