化学性质:
规格 | 1 mg 5 mg 10 mg 25 mg |
CAS | 26581-81-7 |
别名 | N/A |
化学名 | N/A |
分子式 | C13H12N2O3 |
分子量 | 244.2 |
溶解度 | DMF: 5 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml,DMSO: 1 mg/ml |
储存条件 | -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
EM-12 is a derivative of thalidomide with teratogenic activity.1 Intravenous administration of EM-12 (150 mg/kg) to pregnant females induces fetal resorption and skeletal malformation in surviving offspring in rats, rabbits, and rhesus monkeys. Dietary administration of EM-12 (12% w/w) enhances 1,2-dimethylhydrazine-induced colonic adenocarcinoma formation in rats.2
1.Schumacher, H.J., Terapane, J., Jordan, R.L., et al.The teratogenic activity of a thalidomide analogue, EM12 in rabbits, rats, and monkeysTeratology5(2)233-240(1972) 2.Gershbein, L.L.The thalidomide analog, EM 12, enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomasCancer Lett.60(2)129-133(1991)
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标签:EM-12
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