化学性质:
规格 | 2mg 5mg 10mg 25mg 50mg |
CAS | 610318-54-2 |
别名 | N/A |
化学名 | N/A |
分子式 | C34H33ClF3NO3 |
分子量 | 596.08 |
溶解度 | DMSO: ≥ 130 mg/mL (218.09 mM); H2O: < 0.1 mg/mL (insoluble) |
储存条件 | 4°C, protect from light |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
RGX-104 free Acid is an orally bioavailable and potent liver-X nuclear hormone receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the ApoE gene. LXR[1]
Oral administration of RGX-104 (100 mg/kg, daily) to animals bearing palpable tumors significantly suppresses the growth of multiple cancer types. Co-administration of RGX-104 with anti-PD-1 is superior to administration of either RGX-104 or anti-PD-1 alone. Importantly, co-administration of RGX-104 with anti-PD-1 therapy is well tolerated by mice, with no overt signs of toxicity[1]. Animal Model: NOD SCID or RAG mice injected with 1×106 SKOV3 ovarian cancer cells[1].
[1]. Tavazoie MF, et al. LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer. Cell. 2018 Feb 8;172(4):825-840.e18.
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