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Quinestrol is a synthetic estrogen that is effective in hormone replacement therapy after the menopause [1][2].

Estrogen has extraordinarily complex biological effects in diverse tissues such as skeletal, urogenital, digestive, cardiovascular, ocular and nervous systems. Apart from estrogens, selective estrogen receptor modulators may be used for prevention of some of the long-term consequences of estrogen deficiency [2].

Quinestrol is 3-cyclopentyl ether of ethynyl estradiol. After gastrointestinal absorption, Quinestrol is stored in adipose tissue, where it is slowly released and metabolized in the liver to its active form, ethinyl estradiol.

In adult male mice, quinestrol reduced sperm counts and increased the number of abnormal spermatozoa. Quinestrol stimulated oxidative stress to induce apoptosis in spermatogenic cells through the mitochondrial and death receptor pathways [3]. In adult male rat, quinestrol significantly increased the number of germ cells expressing caspase-3, Bax, Fas and FasL, and reduced the number of cells expressing Bcl-2 and PCNA. These results suggested that quinestrol induced abnormal spermatogenesis through the mitochondrial- and Fas-L-mediated pathways [4].

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