化学性质:
规格 | 500μg 1mg 5mg |
CAS | 145022-92-0 |
别名 | Tauro-β-muricholate; TβMCA |
化学名 | 2-[[(3α,5β,6β,7β)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid, monosodium salt |
分子式 | C26H44NO7S • Na |
分子量 | 537.7 |
溶解度 | 1mg/ml in ethanol, 10mg/ml in DMSO & DMF |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Tauro-β-muricholic acid (TβMCA) is a competitive and reversible antagonist of the farnesoid X receptor (FXR; IC50 = 40 µM) and a taurine-conjugated form of the murine-specific primary bile acid β-muricholic acid.[1] TβMCA accumulates in germ-free mice under normal conditions but is reduced after colonization with feces from a human donor.[1],[2] TβMCA is increased in the intestines of mice resistant to high-fat diet-induced obesity, fatty liver, and diabetes.[3]
特别提醒:
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