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Clobetasol propionate-d5 is intended for use as an internal standard for the quantification of clobetasol propionate by GC- or LC-MS. Clobetasol propionate is a corticosteroid.1 It binds to glucocorticoid receptors in a cell-free assay (IC50 = 3.17 nM) and inhibits proliferation of primary human skin fibroblasts when used at a concentration of 5 µg/ml.1,2 Topical administration of clobetasol propionate reduces croton oil-induced ear edema in mice.1 Formulations containing clobetasol propionate have been used in the treatment of inflammatory skin conditions.

1.Ueno, H., Maruyama, A., Miyake, M., et al.Synthesis and evaluation of antiinflammatory activities of a series of corticosteroid 17 α-esters containing a functional groupJ. Med. Chem.34(8)2468-2473(1991) 2.Ponec, M., de Haas, C., Bachra, B.N., et al.Effects of glucocorticosteroids on primary human skin fibroblasts. I. Inhibition of the proliferation of cultured primary human skin and mouse L929 fibroblastsArch. Dermatol. Res.259(12)117-123(1977)

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