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Sauvagine is a neuropeptide hormone that has been found in frog (P. sauvagei) skin and member of the corticotropin-releasing factor (CRF) family, which includes mammalian CRF , urocortin , urocortin II , urocortin III , and piscine urotensin 1.1,2 In vivo, sauvagine (0.5 µg/kg, s.c.) reduces systemic blood pressure in normotensive rats.2 It inhibits anterior pituitary release of prolactin, thyroid-stimulating hormone (TSH), and growth hormone in rats. Sauvagine also increases plasma adrenocorticotropic hormone (ACTH) levels in rats.3

1.AdÃo, R., Santos-Ribeiro, D., Rademaker, M.T., et al.Urocortin 2 in cardiovascular health and diseaseDrug Discov. Today20(7)906-914(2015) 2.Montecucchi, P.C., and Henschen, A.Amino acid composition and sequence analysis of sauvagine, a new active peptide from the skin of Phyllomedusa sauvageiInt. J. Pept. Protein Res.18(2)113-120(1981) 3.Rivier, C., Rivier, J., Lederis, K., et al.In vitro and in vivo ACTH-releasing activity of ovine CRF, sauvagine and urotensin IRegul. Pept.5(2)139-143(1983)

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