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IC50: 1.3 nM for opiate activity

Bovine adrenal medulla 22 peptide (BAM22P) is a peptide with 22 amino acids which is one of the cleavage products of proenkephalin A, the precursor of Leu- and Met-enkephalin, in the adrenal medulla, with very potent opiate activity.

In vitro: In the guinea-pig ileum assay, BAM-22P has been shown to have typical and extraordinarily potent opioid activities antagonized by naloxone. The potency of BAM-22P is 26 times that of Met-enkephalin and 22 times that of B hendorphin. IC50 value of BAM-22P in this tissue, 1.3 nM, makes it the most potent Met-enkephalin relatives that discoveried so far. [1].

In vivo: Intrathecal (i.t.) administration of BAM22 decreased nocifensive behavior scores, which measured as the sum of flinching and lifting/licking, in the first and second phases of the formalin test. Such decrease was partially attenuated by systemic injection of naloxone. [2].

Clinical trial: Up to now, BAM 22P is still in the preclinical development stage..
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