化学性质:
规格 | 1mg |
CAS | 1189477-66-4 |
别名 | N/A |
化学名 | N/A |
分子式 | C12H4D6F3N3O4 |
分子量 | 323.3 |
溶解度 | Soluble in DMSO |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Nilutamide-d6 is intended for use as an internal standard for the quantification of nilutamide by GC- or LC-MS. Nilutamide is a non-steroidal antiandrogen that is an antagonist of the androgen receptor.1 It reverses testosterone-induced increases in cell proliferation with an IC50 value of 412 nM in mouse mammary carcinoma cells in vitro.2 It has antiandrogenic activity in both intact and castrated rats, inhibiting testosterone propionate-induced prostate growth when administered at a dose of 2.5 mg/kg.3 Formulations containing nilutamide have been used in combination with surgical castration in the treatment of metastatic prostate cancer.
|1. Signh, S.M., Gauthier, S., and Labrie, F. Androgen receptor antagonists (antiandrogens): Structure-activity relationships. Curr. Med. Chem. 7(2), 211-247 (2000).|2. Simard, J., Singh, S.M., and Labrie, F. Comparison of in vitro effects of the pure antiandrogens OH-flutamide, Casodex, and nilutamide on androgen-sensitive parameters. Urology 49(4), 580-586 (1997).|3. Wakeling, A.E., Furr, B.J.A., Glen, A.T., et al. Receptor binding and biological activity of steroidal and nonsteroidal antiandrogens. J. Steroid Biochem. 15, 355-359 (1981)..
特别提醒:
1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。
2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
联系人:高小姐
手 机:13585831301
Q Q:3004967995
座 机:021-59541103
传 真:021-60443211
地 址:上海嘉定区嘉罗公路1661