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抑制剂 > 癌症生物学 > Propylthiouracil-d5
产品名称:
Propylthiouracil-d5
型号:
CS-01Y78112
生产地址
国产
产品价格
电议
产品简介
质量保证、价格优惠
产品详情

一、概述:

化学性质:                                                                                                             

规格

2.5 mg

CAS

1189423-94-6

别名

N/A

化学名

N/A

分子式

C7H5D5N2OS

分子量

175.3

溶解度

DMSO: slightly soluble,Methanol: slightly soluble

储存条件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

 

产品描述:                                                                                                            

Propylthiouracil-d5 is intended for use as an internal standard for the quantification of propylthiouracil by GC- or LC-MS. Propylthiouracil (PTU) is a thioamide antithyroid agent.1 It inhibits thyroid peroxidase activity in rat and monkey thyroid microsomes (IC50s = 0.081 and 4.1 μM, respectively). PTU (30 mg/kg) increases thyroid weight and serum thyroid stimulating hormone levels and decreases serum 3,5,3'-triiodothyronine and thyroxine levels in rats. Sensitivity to the bitter taste of PTU is genetically mediated and is associated with increased sensitivity to other sweet and bitter compounds.2 Formulations containing propylthiouracil have been used in the treatment of Graves' disease and hyperthyroidism.

1.Takayama, S., Aihara, K., Onodera, T., et al.Antithyroid effects of propylthiourad and sulfamonomethoxine in rats and monkeysToxicol. Appl. Pharmacol.82(2)191-199(1986) 2.Drewnowski, A., and Rock, C.L.The influence of genetic taste markers on food acceptanceAm. J. Clin. Nutr.62(3)506-511(1995).
特别提醒:                                                                                                              

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。

标签:Propylthiouracil-d5 

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