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Somatostatin-28 is a cyclic neuropeptide hormone that has a role in endocrine regulation.1 It is a somatostatin (SST) receptor agonist that binds to SST1, SST2, SST3, SST4, and SST5 (IC50s = 0.60, 0.12, 0.22, 0.83, and 0.41 nM, respectively, in CCL39 cells expressing human recombinant receptors).2 It inhibits cAMP accumulation induced by forskolin in CCL39 cells expressing human recombinant SST1, SST2, SST3, SST4, and SST5 (EC50s = 5.13, 1.91, 6.46, 2.95, and 3.55 nM, respectively).3 Somatostatin-28 stimulates growth hormone (GH) release from primary porcine pituitary cells when used at a concentration of 1 fM.4 It inhibits acid secretion induced by gastrin I and IBMX in isolated rat gastric mucosa (EC50s = 27 and 252 nM, respectively).5 In vivo, somatostatin-28 dose-dependently increases basal and pentagastrin-induced gastric acid secretion in rats.6

1.Lucey, M.R.Endogenous somatostatin and the gutGut27(4)457-467(1986) 2.Siehler, S., Seuwen, K., and Hoyer, D.Characterisation of human recombinant somatostatin receptors. 1. Radioligand binding studiesNaunyn Schmiedebergs Arch. Pharmacol.360(5)488-499(1999) 3.Siehler, S., and Hoyer, D.Characterisation of human recombinant somatostatin receptors. 3. Modulation of adenylate cyclase activityNaunyn Schmiedebergs Arch. Pharmacol.360(5)510-521(1999) 4.RamÍrez, J.L., Torronteras, R., CastaÑo, J.P., et al.Somatostatin plays a dual, stimulatory/inhibitory role in the control of growth hormone secretion by two somatotrope subpopulations from porcine pituitaryJ. Neuroendocrinol.9(11)841-848(1997) 5.Wyatt, M.A., Jarvie, E., Feniuk, W., et al.Somatostatin sst2 receptor-mediated inhibition of parietal cell function in rat isolated gastric mucosaBr. J. Pharmacol.119(5)905-910(1996) 6.Seefried, G., Schmidtler, J., and Schwille, P.O.Gastric secretion and gastrin under progressive doses of somatostatin-14 and -28 administered intraperitoneally to the ratPeptides9(2)249-255(1988).
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