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抑制剂 > 内分泌和激素 > (S)-Equol
产品名称:
(S)-Equol
型号:
CS-01Y78080
生产地址
国产
产品价格
电议
产品简介
质量保证、价格优惠
产品详情

一、概述:

化学性质:                                                                                                             

规格

1 mg 5 mg 10 mg 25 mg

CAS

531-95-3

别名

N/A

化学名

N/A

分子式

C15H14O3

分子量

242.3

溶解度

DMF: 15 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml

储存条件

-20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

 

产品描述:                                                                                                            

Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora.1,2 The estrogen receptor (ER) agonist activity of the naturally occurring (S)-enantiomer (EC50 = 85 and 65 nM for human ERα and ERβ, respectively) is similar to that of genistein but exceeds that of daidzein.2 (S)-Equol preferentially binds ERβ (Ki = 0.73 nM) and demonstrates approximately 9-fold lower affinity for ERα (Ki = 6.41 nM).1 (S)-equol is also a potent antagonist of dihydrotestosterone, which has important implications for prostate cancer and other androgen-mediated pathologies.3

1.Setchell, K.D.R., Clerici, C., Lephart, E.D., et al.S-equol, a potent ligand for estrogen receptor β, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial floraAm. J. Clin. Nutr.81(5)1072-1079(2005) 2.Muthyala, R.S., Ju, Y.H., Sheng, S., et al.Equol, a natural estrogenic metabolite from soy isoflavones: Convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and betaBioorg. Med. Chem.12(6)1559-1567(2004) 3.Lund, T.D., Munson, D.J., Haldy, M.E., et al.Equol is a novel anti-androgen that inhibits prostate growth and hormone feedbackBiology of Reproduction701188-1195(2004)

特别提醒:                                                                                                              

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。

标签:(S)-Equol 

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