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11β-Hydroxyetiocholanolone is a metabolite of hydrocortisone .1 Fecal levels of 11β-hydroxyetiocholanolone are increased in response to environmental stress in giraffes (G. camelopardalis) and plains zebras (E. quagga).2,3

1.Shackleton, C.H.L., Neres, M.S., Hughes, B.A., et al.17-Hydroxylase/C17,20-lyase (CYP17) is not the enzyme responsible for side-chain cleavage of cortisol and its metabolitesSteroids73(6)652-656(2008) 2.Bashaw, M.J., Sicks, F., Palme, R., et al.Non-invasive assessment of adrenocortical activity as a measure of stress in giraffe (Giraffa camelopardalis)BMC Vet. Res.12(1)235(2016) 3.Seeber, P.A., Franz, M., Dehnhard, M., et al.Plains zebra (Equus quagga) adrenocortical activity increases during times of large aggregations in the Serengeti ecosystemHorm. Behav.1021-9(2018)

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