化学性质:
规格 | 5mg 10mg 25mg 50mg 100mg |
CAS | 108237-91-8 |
别名 | N/A |
化学名 | N/A |
分子式 | C15H11BrN2S |
分子量 | 331.23 |
溶解度 | DMSO : ≥ 160 mg/mL (483.05 mM);H2O : < 0.1 mg/mL (insoluble) |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair.
RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair[1].
RCGD423 greatly reduces chondrocyte hypertrophy, loss and degeneration while increasing chondrocyte proliferation beyond that observed in response to injury in a rat partial meniscectomy model. Moreover, RCGD 423 improves cartilage healing in a rat full-thickness osteochondral defect model, increasing proliferation of mesenchymal cells in the defect and also inhibiting breakdown of cartilage matrix in de novo generated cartilage[1].
[1]. Shkhyan R, et al. Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair. Ann Rheum Dis. 2018 May;77(5):760-769.
特别提醒:
1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。
2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
标签:RCGD423
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