RoxatidineCS-01Y78016_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	500 μg 1 mg 5 mg 10 mg
CAS	78273-80-0
别名	N/A
化学名	N/A
分子式	C17H26N2O3
分子量	306.4
溶解度	DMSO: up to 25 mg/ml
储存条件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

Roxatidine is a histamine H2 receptor antagonist and major active metabolite of roxatidine acetate .1 Roxatidine reduces histamine-induced adenylate cyclase production in guinea pig parietal cells (IC50 = 0.8 μM). It inhibits histamine-induced hydrogen ion accumulation in the same cells (pA2 = 7.03). Roxatidine (200 mg/kg) reduces small intestinal lesion area in a rat model of gastric mucosal injury induced by indomethacin .2

1.Sewing, K.-F., Beil, W., and Hannemann, H.Comparative pharmacology of histamine H2-receptor antagonistsDrugs35(Suppl. 3)25-29(1988) 2.Umegaki, E., Yoda, Y., Tokioka, S., et al.Protective effect of roxatidine against indomethacin induced small intestinal mucosal injury in ratsJ. Gastroenterol. Hepatol.25(Suppl. 1)S35-S40(2010)

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2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

标签：Roxatidine

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