化学性质:
规格 | 1mg 5mg 10mg 20mg |
CAS | 13 |
别名 | N/A |
化学名 | N/A |
分子式 | C13H12ClNOS2 |
分子量 | 297.82 |
溶解度 | DMSO : 62.5 mg/mL (209.86 mM);H2O : < 0.1 mg/mL (insoluble) |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
RP 54745 is an inhibitor of macrophage stimulation and interleukin-1 production, and a potential antirheumatic compound.
RP 54745 diminishes LPS-induced interleukin-1 (IL-1) production by murine peritoneal macrophages[1].
RP 54745 (5 mg/kg) is effective at moderating oral doses in different mouse models of induced arthritis and in the MRL/lpr mice, genetically predisposed to develop an autoimmune pathology including arthritic disorders. The clinical status of the MRL mice, and several of their disturbed biochemical and immunological parameters, improved after a 3-month treatment with RP 54745[2].
[1]. Folliard F, et al. RP 54745, a potential antirheumatic compound. I. Inhibitor of macrophage stimulation and interleukin-1 production. Agents Actions. 1992 May;36(1-2):119-26. [2]. Folliard F, et al. RP 54745, a potential antirheumatic compound. II. In vivo properties in different animal models. Agents Actions. 1992 May;36(1-2):127-35.
特别提醒:
1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。
2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
标签:RP-54745
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