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Thymohydroquinone is a quinone that has been found in N. sativa seeds and has diverse biological activities.1,2 It scavenges 2,2-diphenyl-1-picrylhydrazyl free radicals in a cell-free assay (IC50 = 2.4 μg/ml) and has a Trolox equivalent value of 2.6 in an oxygen radical absorbance capacity (ORAC) assay when used at concentrations ranging from 1.6 to 6.4 μg/ml.1 Thymohydroquinone inhibits growth of A2780, OVCAR-8, and CIS-A2780 ovarian cancer cells (IC50s = 3.1, 8.9, and 9.8 μM, respectively), as well as immortalized human ovarian epithelial cells (IC50 = 14 μM).2 It is also active against P. falciparum in vitro (IC50 = 15.9 μM).

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