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抑制剂 > 免疫学/炎症 > [D-Trp8]-γ-MSH (trifluoroacetate salt)
产品名称:
[D-Trp8]-γ-MSH (trifluoroacetate salt)
型号:
CS-01Y77978
生产地址
国产
产品价格
电议
产品简介
质量保证、价格优惠
产品详情

一、概述:

化学性质:                                                                                                             

规格

1 mg 5 mg 10 mg 25 mg

CAS

N/A

别名

N/A

化学名

N/A

分子式

C74H99N21O16S ? XCF3COOH

分子量

1570.8

溶解度

Water: soluble

储存条件

-20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

 

产品描述:                                                                                                            

[D-Trp8]-γ-MSH is a melanocortin receptor 3 (MC3R) agonist and an analog of γ-melanocyte-stimulating hormone (γ-MSH).1 It selectively induces cAMP accumulation in cells expressing MC3R over cells expressing MC4R or MC5R (EC50s = 0.33, 100, and 82 nM, respectively, for the human receptors). In vivo, [D-Trp8]-γ-MSH (162 nmol/kg, i.v.) reduces the incidence of ventricular tachycardia, ventricular fibrillation, and death in a rat model of myocardial ischemia-reperfusion injury.2 It also inhibits urate-induced chemokine (C-X-C) motif ligand 1 (CXCL1) release and peritoneal polymorphonuclear leukocyte accumulation in recessive yellow (e/e) mice with a non-functional MC1R.3

1.Grieco, P., Balse, P.M., Weinberg, D., et al.D-Amino acid scan of γ-melanocyte-stimulating hormone: Importance of Trp8 on human MC3 receptor selectivityJ. Med. Chem.43(26)4998-5002(2000) 2.Mioni, C., Giuliani, D., Cainazzo, M.M., et al.Further evidence that melanocortins prevent myocardial reperfusion injury by activating melanocortin MC3 receptorsEur. J. Pharmacol.477(3)227-234(2003) 3.Getting, S.J., Lam, C.W., Leoni, G., et al.[D-Trp8]-γ-melanocyte-stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse)Mol. Pharmacol.70(6)1850-1855(2006)

特别提醒:                                                                                                              

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。

标签:[D-Trp8]-γ-MSH (trifluoroacetate salt) 

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