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Naphazoline-d4 is intended for use as an internal standard for the quantification of naphazoline by GC- or LC-MS. Naphazoline is a vasoconstrictor.1 In vivo, naphazoline (0.1 mg/kg, i.v.) decreases specific airway resistance and reverses intranasal blockage induced by U-46619 or leukotriene D4 in guinea pigs. Formulations containing naphazoline have been used to treat allergic conjunctivitis and as nasal decongestants.

1.Tanaka, Y., Mizutani, N., Fujii, M., et al.Different mechanisms between thromboxane A2- and leukotriene D4-induced nasal blockage in guinea pigsProstaglandins Other Lipid Mediat.80(3-4)144-154(2006).
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