化学性质:
规格 | 25mg 50mg 100mg |
CAS | 73069-27-9 |
别名 | N/A |
化学名 | N/A |
分子式 | C21H22O7 |
分子量 | 386.4 |
溶解度 | DMF: 30 mg/ml,DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml,DMSO: 20 mg/ml,Ethanol: 10 mg/ml |
储存条件 | 4°C, protect from light |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
(+)-Praeruptorin A is a coumarin derivative originally isolated from P. praeruptorum. It prevents LPS-induced increases in IL-1β and TNF-α in a concentration-dependent manner when used at concentrations ranging from 6.25 to 100 μM and IL-6 at concentrations ranging from 25 to 100 μM. It inhibits potassium chloride-induced contraction of isolated rabbit trachea by 50 and 100% when used at concentrations of 4.8 and 30 μM, respectively. Topical administration of (+)-praeruptorin A (0.3 μmol/cm2) reduces edema by 22% in a croton oil mouse model of inflammation..
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