CU-76CS-01Y77728_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	1 mg 5 mg 10 mg
CAS	2400954-58-5
别名	N/A
化学名	N/A
分子式	C11H8F2IN5O2
分子量	407.1
溶解度	DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:5): 0.1 mg/ml
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS; IC50 = 0.24 μM).1 It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. CU-76 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM.

1.Padilla-Salinas, R., Sun, L., Anderson, R., et al.Discovery of small-molecule cyclic GMP-AMP synthase inhibitorsJ. Org. Chem.85(3)1579-1600(2020)

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2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

标签：CU-76

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