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(±)-α-Tocopherol acetate is an acetate form of (±)-α-tocopherol , a biologically active form of vitamin E. It prevents reductions in the percentage of embryos developing into blastocysts and the levels of glutathione (GSH), as well as prevents increases in oxidative stress, in zygotes from mice exposed to heat stress prior to mating when administered to dams prior to heat stress at a dose of 1 g/kg.1 (±)-α-Tocopherol acetate (>1,050 IU/kg in the diet) prevents body weight loss and prevents decreases in pulmonary dynamic compliance in mice exposed to sidestream cigarette smoke but not in sham exposure animals.2 However, it also increases the levels of IL-1β, IL-4, and IFN-γ in the bronchoalveolar lavage fluid (BALF) of sidestream cigarette-exposed, but not sham exposure, mice.

|1. Sakamoto, N., Ozawa, M., Yokotani-Tomita, K., et al. DL-α-Tocopherol acetate mitigates maternal hyperthermia-induced pre-implantation embryonic death accompanied by a reduction of physiological oxidative stress in mice. Reproduction 135(4), 489-496 (2008).|2. Wang, S., Sun, N.N., Zhang, J., et al. Immunomodulatory effects of high-dose α-tocopherol acetate on mice subjected to sidestream cigarette smoke. Toxicology 175(1-3), 235-245 (2002).

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