上海莼试生物技术有限公司
上海莼试生物技术有限公司
化学性质：
| 规格 | 5 mg 10 mg 25 mg 50 mg 100 mg |
| CAS | 2380032-29-9 |
| 别名 | N/A |
| 化学名 | N/A |
| 分子式 | C19H23N4NaO3S |
| 分子量 | 410.47 |
| 溶解度 | DMSO : 240 mg/mL (584.70 mM; Need ultrasonic) |
| 储存条件 | -20°C, away from moisture |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述：
MCC7840 sodium, a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM. MCC7840 sodium can be used for the research of inflammatory diseases[1][2].
MCC7840, a MCC950 analogue, shows useful activity in the inhibition of activation of the NLRP3 inflammasome, with an IC50 of <100 nM[1].
MCC7840 (4 mg/kg; i.v.) exhibits the half-life (3.39 h), AUC0-last (107097 ng?h/mL) and CL (0.621 mL/min/kg) in mice[2].MCC7840 (20 mg/kg; p.o.) exhibits the oral bioavailability (67.2%), Cmax (60467 ng/mL) and half-life (5.02 h) in mice[2].
[1]. El-Sharkawy LY, et, al. Inhibiting the NLRP3 Inflammasome. Molecules. 2020 Nov 25;25(23):5533.
[2]. O’neill L, et, al. Sulfonylureas and related compounds and use of same. WO2016131098A1.
特别提醒：
1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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