ZK118182 isopropyl esterCS-01Y77454_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	100μg 500μg
CAS	154927-31-8
别名	N/A
化学名	N/A
分子式	C23H37ClO5
分子量	429
溶解度	DMF: 3 mg/ml,DMSO: 2 mg/ml,Ethanol: 12.5 mg/ml,Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins (PGs) such as PGF2α and PGD2, have been shown to reduce IOP. ZK118182 is a PG analog that has potent DP-agonist activity (EC50 = 16.5 nM) and a high nanomolar affinity for the DP receptor (Ki = 74 nM). ZK118182 isopropyl ester is a prodrug formulation of ZK118182 designed to enhance corneal absorption. At 0.03 μg, ZK118182 isopropyl ester has been shown to lower monkey and rabbit IOP 46% and 20%, respectively, two hours after dosing, demonstrating a much more potent effect compared to the free acid.

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1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

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标签：ZK118182 isopropyl ester

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