Valdecoxib-d3CS-01Y77365_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	1 mg 5 mg
CAS	1219794-90-7
别名	N/A
化学名	N/A
分子式	C16H11D3N2O3S
分子量	317.4
溶解度	DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 5 mg/ml
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

Valdecoxib-d3 is intended for use as an internal standard for the quantification of valdecoxib by GC- or LC-MS. Valdecoxib is a selective inhibitor of COX-2 (IC50s = 0.005 and 140 µM, for human recombinant COX-2 and COX-1, respectively).1 It decreases LPS-induced production of prostaglandin E2 in isolated human whole blood (IC50 = 0.89 µM). Valdecoxib reduces carrageenan-induced paw edema and adjuvant-induced arthritis in rats (ED50s = 10.2 and 0.032 mg/kg, respectively).

1.Talley, J.J., Brown, D.L., Carter, J.S., et al.4-[5-Methyl-3-phenylisoxazol-4-yl]-benzenesulfonamide, valdecoxib: A potent and selective inhibitor of COX-2J. Med. Chem.43(5)775-777(2000)

特别提醒：

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

标签：Valdecoxib-d3

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