化学性质：                                                                                                             

产品描述：                                                                                                            

Spinosyn A is an insect nicotinic acetylcholinesterase receptors (nAChRs) agonist and potent insecticide.

The spinosyns are a family of macrolide natural products produced by the soil microorganism Saccharopolyspora spinosa. Spinosyn A is identified as a naturally-occurring macrocyclic lactone that is a potent insecticide.

In vitro: The mixture of spinosyns A and D, a commercial insecticide TracerTM (DowAgroSciences), is useful against various crop pests such as tobacco budworm. It was found that the deoxy analogs of spinosyns A were more potent insecticides than their respective parent factor. Moreover, the 2’-desmethoxy analogs of spinosyns A showed insecticidal potency against H. virescens greater than that of spinosyns A and D, suggesting that polarity was not well tolerated. Furthermore, the activity of 3'-deoxy spinosyn J was about the same as spinosyn A, and the activity of 2'-deoxy spinosyn H was found to be slightly greater than that of spinosyn A [1].

In vivo: Currently, there is no animal in vivo data reported.

Clinical trial: So far, no clinical study has been conducted.

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