化学性质:
规格 | 10mg 50mg |
CAS | 298690-60-5 |
别名 |
|
化学名 | (S)-2-(4-fluorophenyl)-1-tosylpyrrolidine |
分子式 | C17H18FNO2S |
分子量 | 319.39 |
溶解度 | DMSO: 30 mg/ml |
储存条件 | Store at RT |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. Displays no activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM.target: mGlu1 EC 50: 60.1 nM(1) Ro 67-7476 (10 μM) can directly block the GIRK channel (to 67 ± 2% of control). (2) Ro 67-7476 enhance the glutamate-induced current in all chimeric receptors containing the transmembrane (TM) region of rmGlu1a (R1, R1-R5N, R1-R5C, and R5-R1TM) but not in those containing the TM region of rmGlu5a (R5, R5-R1N, R5-R1C, and R1-R5TM.(3) The application of Ro 67-7476 (3 μM) produced no effect alone but resulted in a marked potentiation of the mGlu1 EPSC amplitude.
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