化学性质:
规格 | 5mg 25mg 50mg 100mg 200mg 500mg |
CAS | 179386-44-8 |
别名 | N/A |
化学名 | N/A |
分子式 | C15H17N3O5 |
分子量 | 319.31 |
溶解度 | DMSO: 50 mg/mL (156.59 mM); H2O: 10 mg/mL (31.32 mM) |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Sumanirole maleate(PNU 95666E; U95666E) is a highly selective D2 receptor full agonist with an ED50 of about 46 nM.IC50 value: 46 nM (EC50)Target: D2 receptorSumanirole was developed for the treatment of Parkinson's disease and restless leg syndrome. While it has never been approved for medical use. Sumanirole is a highly valuable tool compound for basic research to identify neurobiological mechanisms that are based on a dopamine D2-linked (vs. D1, D3, D4, and D5-linked) mechanism of action.
[1]. Arthur G. Romero, et al. Synthesis of the Selective D2 Receptor Agonist PNU-95666E fromD-Phenylalanine Using a Sequential Oxidative CyclizationStrategy. J. Org. Chem. 1997, 62, 6582-6587
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