化学性质:
规格 | 500μg 1mg 5mg 10mg |
CAS | 33854-16-9 |
别名 | N/A |
化学名 | 9α,11α,15S-trihydroxy-prosta-5Z,13E-dien-1-oic acid, methyl ester |
分子式 | C21H36O5 |
分子量 | 368.5 |
溶解度 | DMF: 35 mg/ml,DMSO: 35 mg/ml,Ethanol: 50 mg/ml,Ethanol:PBS (pH 7.2) (1:4): 0.4 mg/ml |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Prostaglandin F2α methyl ester (PGF2α methyl ester) is an analog of PGF2α in which the C-1 carboxyl group has been esterified as the methyl ester. PGF2α methyl ester was one of the first PG esters shown to have ocular hypotensive activity. This compound continues to be a standard by which other ocular hypotensive PG prodrugs are evaluated. The methyl ester is about 4-5 times more potent than the free acid, PGF2α. This difference is attributed to improved corneal penetration, and a depot effect of prolonged retention of the ester form of the compound in ocular tissue. A 2.5 ug dose of PGF2α-OMe applied to the eyes of cats results in a 6-8 mm Hg reduction in IOP.
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