TAT-Gap19CS-01Y76984_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	1 mg
CAS	1507930-54-2
别名	N/A
化学名	N/A
分子式	C119H212N46O26
分子量	2703.28
溶解度	Soluble in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

Cx43 hemichannel blocker (IC50 ~7 μM). No significant affinity for gap junctions or Panx1 channels. N-terminal transactivator of transcription (TAT) motif promotes membrane permeability and increases inhibitory effect of Gap19 . Active in vivo. Brain penetrant.

Abudara et al (2014) The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front.Cell.Neurosci. 8 1 PMID:25374505 |Freitas-Andrade and Naus (2016) Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1. Neuroscience. 323 207 PMID:25913636

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标签：TAT-Gap19

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抑制剂 > 神经科学 > TAT-Gap19

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