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Isocarboxazid is a non-selective and irreversible inhibitor of monoamine oxidase, with an IC50 of 4.8 μM for rat brain monoamine oxidase in vitro[1].

Isocarboxazid (1, 3 mg/kg, i.p., 60 min) pretreatment in mice shows the significant increased number of head twitches at 15 and 30 min after 5-HTP[2].Isocarboxazid (1, 3 mg/kg, i.p., 60 min) treatment in mice together with 5-HTP administration causes 43% 5-HT concentration increased and 22% of 5-HIAA decreased compared to brain concentrations in mice given 5-HTP alone[2].|| Animal Model:|Twelve male mice of dd strain (20-25 g)[2]|Dosage:|0, 0.3,1, 3 mg/kg|Administration:|Intraperitoneally 60 min before intravenous injection of 5-HTP|Result:|The number of head twitches at 15 and 30 min after 5-HTP was increased.43% 5-HT concentration increased and 22% of 5-HIAA decreased.

[1]. MAXWELL DR, et al. Relative activity of some inhibitors of mono-amine oxidase in potentiating the action of tryptamine in vitro and in vivo. Br J Pharmacol Chemother. 1961 Dec;17:310-20.

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