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N-methyl Mesoporphyrin IX is a transition state analog of porphyrin and an inhibitor of ferrochelatase.[1] It inhibits ferrochelatase in mouse liver mitochondria in vitro and in vivo, leading to an accumulation of porphyrin in isolated liver mitochondria following administration of an intravenous dose of 80 nmol. N-methyl Mesoporphyrin IX has been used as a turn-on biosensor for target DNA sequences when used in complex with a G-quadruplex-forming sequence fused to a DNA sequence complementary to the target sequence.[2] It has also been used to detect amyloid-β (1-40) (Aβ40) fibrils in vitro and in live PC12 cells overexpressing Aβ.[3] N-methyl Mesoporphyrin displays excitation/emission maxima of 399/610 nm, respectively.[4]

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