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Isoreserpiline is an indole alkaloid that has been found in R. tetraphylla and has diverse biological activities.1,2 It has a synergistic effect on the antibacterial activity induced by nalidixic acid in nalidixic acid-sensitive and -resistant strains of E. coli.2 It also reduces amphetamine-induced hyperactivity in mice when administered at a dose of 25 mg/kg.1

1.Gupta, S., Khanna, V.K., Maurya, A., et al.Bioactivity guided isolation of antipsychotic constituents from the leaves of Rauwolfia tetraphylla L.Fitoterapia83(6)1092-1099(2012) 2.Dwivedi, G.R., Gupta, S., Maurya, A., et al.Synergy potential of indole alkaloids and its derivative against drug-resistant Escherichia coliChem. Biol. Drug Des.86(6)1471-1481(2015)

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