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L-Glutamine-d5 is intended for use as an internal standard for the quantification of L-glutamine by GC- or LC-MS. L-Glutamine is a non-essential amino acid involved in many biochemical processes. It is synthesized in vivo by glutamate and ammonia.1 It serves as a substrate for glutamine synthetase in neurons for the biosynthesis of the major excitatory and inhibitory neurotransmitters glutamate and GABA.2 L-Glutamine decreases adhesion of sickle red blood cells (RBCs) to human umbilical vein endothelial cells (HUVECs) when incubated ex vivo with patient-derived autologous plasma either alone or with LPS.3 It has commonly been used in cell culture media. Formulations containing L-glutamine have been used in the treatment of sickle cell disease.

1.Eisenberg, D., Gill, H.S., Pfluegl, G.M.U., et al.Structure-function relationships of glutamine synthetasesBiochim Biophys. Acta.1477(1-2)122-145(2000) 2.Bak, L.K., Schousboe, A., and Waagepetersen, H.S.The glutamate/GABA-glutamine cycle: Aspects of transport, neurotransmitter homeostasis and ammonia transferJ. Neurochem.98(3)641-653(2006) 3.Niihara, Y., Matsui, N.M., Shen, Y.M., et al.L-glutamine therapy reduces endothelial adhesion of sickle red blood cells to human umbilical vein endothelial cellsBMC Blood Disord.5(4)(2005)

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