Pavinetant (MLE-4901)CS-01Y76755_上海莼试生物技术有限公司

产品详情

一、概述：

化学性质：

规格	5mg 10mg 25mg 50mg 100mg
CAS	941690-55-7
别名	N/A
化学名	N/A
分子式	C26H25N3O3S
分子量	459.56
溶解度	DMSO : ≥ 50 mg/mL (108.80 mM);H2O : < 0.1 mg/mL (insoluble)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

Pavinetant (MLE-4901) is a neurokinin-3 receptor (NK3R) antagonist.

Pavinetant (AZD2624) is a potent and selective NK3 receptor antagonist which is developed for the treatment of schizophrenia. Pavinetant exhibits an inhibitory effect on microsomal CYP3A4/5 activities with apparent IC50 values of 7.1 and 19.8 μM for midazolam and testosterone assays, respectively. No time-dependent inactivation of CYP3A4/5 activity by Pavinetant is observed. Pavinetant demonstrates weak to no inhibition of CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, and CYP2D6[1].

[1]. Li Y, et al. In vitro assessment of metabolic drug-drug interaction potential of AZD2624, neurokinin-3 receptor antagonist, through cytochrome P(450) enzyme identification, inhibition, and induction studies. Xenobiotica. 2010 Nov;40(11):721-9.

特别提醒：

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

标签：Pavinetant (MLE-4901)

热卖产品最新促销最新推荐

抑制剂 > 神经科学 > Pavinetant (MLE-4901)

产品简介

产品详情

一、概述：

联系我们