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Galnon is a galanin (GAL) receptor agonist (KD = 2.9 μM in Bowes cells expressing GAL1 receptors).1 It inhibits forskolin-induced adenylate cyclase activity in rat hippocampal membranes (EC50 = 10 μM). Galnon (2 mg/kg) reduces the maximal seizure score and increases the latency to first seizure in a mouse model of seizure induced by pentylenetetrazole . It reduces cocaine-induced motor activity and frontal cortex, but not nucleus accumbens, dopamine overflow, as well as blocks cocaine-primed reinstatement of cocaine-seeking behavior in rats.2 Galnon (1.5-5 mg/kg) reduces food intake in rats and mice.3

1.Saar, K., Mazarati, A.M., Mahlapuu, R., et al.Anticonvulsant activity of a nonpeptide galanin receptor agonistProc. Natl. Acad. Sci. USA99(10)7136-7141(2002) 2.Ogbonmwan, Y.E., Sciolino, N.R., Groves-Chapman, J.L., et al.The galanin receptor agonist, galnon, attenuates cocaine-induced reinstatement and dopamine overflow in the frontal cortexAddict. Biol.20(4)701-713(2015) 3.Abramov, U., Florén, A., Echevarria, D.J., et al.Regulation of feeding by galnonNeuropeptides38(1)55-61(2004)

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