化学性质：                                                                                                             

产品描述：                                                                                                            

FR122047 is a selective inhibitor of cyclooxygenase (COX)-1 [1].

Cyclooxygenase (COX)-1 is constitutively expressed in almost all tissues. COX-1 gene has been considered to be a “housekeeping” gene. COX-1 has been responsible for the production of prostaglandins (PG) that are important for homeostatic functions, such as mediating normal platelet function, maintaining the integrity of the gastric mucosa, and regulating renal blood flow [2].

In recombinant human cyclooxygenase enzyme assays, FR122047 inhibited the activity of recombinant human cyclooxygenase-1 and cyclooxygenase-2 with the IC50 values of 0.028 ± 0.009 and 65 ± 19 μM for cyclooxygenase-1 and cyclooxygenase-2, respectively [1]. In MCF-7 cells, FR122047 treatment suppressed cell growth. Treatment with FR122047 apparently increased the ratio of Bax to Bcl-2, mitochondrial cytochrome c release, and apoptosis [3]. In rat type II collagen-induced arthritis (CIA) and adjuvant-induced arthritis (AIA), oral administration of FR122047 showed anti-inflammatory effect in a dose-dependent manner with ED50 value of 0.56 mg/kg [4]. In guinea-pigs, oral administration of FR122047 inhibited arachidonic acid- and collagen-induced aggregation with an ED50 value of 280 μg/kg and 530 μg/kg, respectively [5].

特别提醒：