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Oxyphenonium is an antagonist of muscarinic acetylcholine receptors that binds to muscarinic receptors on isolated guinea pig atria and ileum (Kds = 0.11 and 0.17 nM, respectively). In vivo, oxyphenonium reverses carbaminocholine- and acetylcholine-induced decreases in blood pressure in anesthetized cats (ED50s = 0.591 and 1 μg/kg, respectively). It decreases rumenal ulcer formation in rats and suppresses insulin-induced gastric secretion in dogs with gastric fistulas. Oxyphenonium also prevents form-deprivation myopia (FDM) in a chick model of experimental myopia. Formulations containing oxyphenonium have been used to treat peptic ulcers.

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