NPC-15437 (hydrochloride)CS-01Y76467_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	500μg 1mg 5mg
CAS	141774-20-1
别名	N/A
化学名	(2S)-2,6-diamino-N-[[1-(1-oxotridecyl)-2-piperidinyl]methyl]-hexanamide, dihydrochloride
分子式	C25H50N4O2.2HCl
分子量	511.6
溶解度	DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 1 mg/ml
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

NPC-15437 is a selective protein kinase C (PKC) inhibitor (IC50 = 19 uM). It competitively inhibits phorbol ester- (Ki = 5 uM) and phosphatidylserine-induced (Ki = 12 uM) PKC activity but does not affect the activity of cAMP-dependent or Ca2+/calmodulin-dependent protein kinases. PKC signaling is involved in learning and memory, and when NPC-15437 was administered after Y maze training (0.1-10 mg/kg i.p.), it led to memory retention deficits in mice.

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1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

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标签：NPC-15437 (hydrochloride)

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