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INNO-8875 is an adenosine A1 receptor agonist.1,2 It binds to adenosine A1 receptors (Ki = 0.97 nM) and is greater than 10,000-fold selective for adenosine A1 over A2 receptors. Topical application of INNO-8875 (25 µg/eye) reduces intraocular pressure in a rabbit model of ocular hypertension.2 INNO-8875 (1-50 µg/kg) decreases atrial refractoriness and heart rate, as well as slows atrioventricular nodal conduction, in anesthetized rats.1

1.Mor, M., Shalev, A., Dror, S., et al.INO-8875, a highly selective A1 adenosine receptor agonist: Evaluation of chronotropic, dromotropic, and hemodynamic effects in ratsJ. Pharmacol. Exp. Ther.344(1)59-67(2012) 2.Kim, N., Crosson, C., Supuran, C., et al.INO-8875, an adenosine A1 agonist, in development for open-angle glaucoma reduces IOP in three rabbit modelsInvert. Ophthalmol. Vis. Sci.50(13)4061(2009)

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