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Ipidacrine is an inhibitor of acetylcholinesterase (AChE; IC50 = 270 nM).1 It induces long-term potentiation (LTP) in rat hippocampal slices, an effect that can be blocked by the muscarinic antagonists atropine or pirenzepine , when used at a concentration of 10 µM.2 Ipidacrine (0.03-1 mg/kg) prevents memory deficits induced by the anticholinergic agent scopolamine in the passive avoidance test in rats.2

1.Ogura, H., Kosasa, T., Kuriya, Y., et al.Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitroMethods Find. Exp. Clin. Pharmacol.22(8)609-613(2000) 2.Yoshida, S., and Suzuki, N.Antiamnesic and cholinomimetic side-effects of the cholinesterase inhibitors, physostigmine, tacrine and NIK-247 in ratsEur. J. Pharmacol.250(1)117-124(1993)

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